Cholesterol-lowering Sterols and Stanols
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چکیده
Unfortunately, whilst the in vitro evidence for their beneficial effects on lipid profile is convincing, this does not translate with any compelling degree into prevention of primary cardiovascular events. Except in borderline normo/hypercholesterolaemia, prescription drugs (eg, statins) are more effective than stanol/sterol esters for lowering LDL cholesterol. The National Institute for Health and Care Excellence (NICE) does not recommend routinely advising patients to use them, until results of randomised controlled trials are known [3] .
منابع مشابه
LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies
Phytosterols (PS, comprising plant sterols and plant stanols) have been proven to lower LDL-cholesterol concentrations. The dose-response relationship for this effect has been evaluated in several meta-analyses by calculating averages for different dose ranges or by applying continuous dose-response functions. Both approaches have advantages and disadvantages. So far, the calculation of average...
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Several studies have shown that increased levels of low-density lipoprotein (LDL) cholesterol predict cardiovascular events. The Adult Treatment Panel II (ATP II) introduced the principle of therapeutic lifestyle changes, including plant sterols/stanols for the management of LDL cholesterol. Plant sterols and stanols in fat matrices effectively lower LDL cholesterol levels in hypercholesterolem...
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Foods with plant stanol or sterol esters lower serum cholesterol levels. We summarize the deliberations of 32 experts on the efficacy and safety of sterols and stanols. A meta-analysis of 41 trials showed that intake of 2 g/d of stanols or sterols reduced low-density lipoprotein (LDL) by 10%; higher intakes added little. Efficacy is similar for sterols and stanols, but the food form may substan...
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Background: Plant sterols, in various forms, have been shown to reduce total and LDL-cholesterol concentrations. Particularly controversial at present is the effect of the degree of hydrogenation of the plant sterols on cholesterol-lowering efficacy and the responsible mechanisms. Objective: Our goal was to examine the effect of supplementation with unesterified plant sterols and stanols on pla...
متن کاملUnesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons.
BACKGROUND Plant sterols, in various forms, have been shown to reduce total and LDL-cholesterol concentrations. Particularly controversial at present is the effect of the degree of hydrogenation of the plant sterols on cholesterol-lowering efficacy and the responsible mechanisms. OBJECTIVE Our goal was to examine the effect of supplementation with unesterified plant sterols and stanols on pla...
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Plant sterols and stanols are structurally similar to cholesterol and when added to the diet they are able to reduce serum total- and LDL-cholesterol concentrations. They also lower serum triglyceride concentrations in humans, particularly under conditions of hypertriglyceridemia. The aim of this study was to unravel the mechanism by which plant sterols and stanols reduce serum triglyceride con...
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